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Wu Sang-wook| Warfarin’s mechanism of anticoagulation has been identified
WRITER 대외협력과 WRITE DAY 2020-04-24
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Wu Sang-wook| Warfarin’s mechanism of anticoagulation has been identified
대외협력과 2020-04-24 243

Warfarin’s mechanism of anticoagulation has been identified
Professor Wu Sang-wook

The research results by Professor Wu Sang-wook (Dept. of Physics) of Pukyong National University have found that warfarin molecule binds to the binding pocket of vitamin K oxidoreductase. According to the research results, the warfarin molecule was found to bind to a specific protein site known as TYA (threonine-tyrosine-alanine) among vitamin K oxidoreductases, that is, a binding pocket. Professor Wu systematically reproduced the process of combining the warfarin molecule and the vitamin K oxidoreductase molecule using a computer simulation technique, molecular dynamics simulation, and realized it as a 3 dimensional image. Until now, it has been known that warfarin inhibits blood coagulation in a way that binds to the vitamin K oxidoreductase in the human body’s biofilm, but it has not been found to know the specific structure. Professor Wu conducted this research in collaboration with the Department of Biology and Chemistry at North Carolina State University in the United States. The paper ’Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition,’ has been published in the international journal in biology, ’Blood’ (IF=13.164) <기사 보러가기(클릭!)>


△ Warfarin molecule and vitamin K oxidoreductase binding image 
(Warfarin molecule (yellow) is placed in the binding pocket of vitamin K oxidoreductase (green))


5 July 2018



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