NEW BEGINNING, NEW INSPIRATION
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“Moisture Cycles Significantly Influence Urban Climate”: Development of the Next-Generation Urban Climate Model ‘BECLOUD’- Research team led by Professor Kim Jae-Jin of Pukyong National University develops a next-generation CFD model that precisely simulates urban moisture and phase-change processes- Published in the international journal
Pukyong National University Professor Kim Jong-Hyeong ‘Draws Attention’ for Research on Eco-Friendly Semiconductors and Ultra-Sensitive Sensors- Consecutive publications in SCIE journals; global research achievements expanded with support from the RISE program Professor Kim Jong-Hyeong (Major in Materials Engineering) at Pukyong National University has recently gained international attention by presenting a series of notable research achievements in the fields of eco-friendly semiconductor materials and next-generation sensor technologies. Professor Kim recently published a paper titled “Dissolution study of biodegradable Magnesium Silicide thin films for transient electronic applications” in the renowned SCIE-indexed international journal
‘Blocking Pain Signals Without Drugs’ Featured as a Cover Article in an International Journal- Research team led by Professor Sung Min-Ho of Pukyong National University develops a biodegradable heat-based technology for blocking neural pain signals- Published in the materials science journal
“A Click of the Switch Selectively Cuts Target Molecular Bonds”- Pukyong National University and RWTH Aachen University (Germany) Develop a DNA-Based Ultrasound Molecular Switch- Selective bond cleavage achieved even under low-intensity ultrasound; expected applications in drug delivery and biosensors Opening New Possibilities for DNA-Based Ultrasound Mechanophores A research team led by Professor Kwak Min-Seok of the Department of Chemistry at Pukyong National University, in collaboration with the team of Professor Andreas Herrmann at RWTH Aachen University (Germany), has developed a DNA-based molecular switch (mechanophore) platform (DNA-MP-DNA) designed to selectively cleave specific molecular bonds when activated by the mechanical ‘force signal’ of ultrasound. This technology has attracted attention for simultaneously addressing the low reaction efficiency and non-specific bond cleavage commonly observed in conventional polymer-based ultrasound mechanochemistry. Previously, mechanophores were connected to flexible polymer chains to transmit ultrasonic forces. However, because of the flexible structure of polymers, the ultrasonic energy tended to disperse, making it difficult to deliver force precisely to the target bond. As a result, unintended bonds could break first or reaction times could become prolonged. To overcome these limitations, the research team focused on the DNA double helix, which combines structural stability with partial flexibility. Compared with conventional polymers, DNA’s higher structural stability makes it more suitable for concentrating ultrasonic energy on the mechanophore site. Development of a Precision Platform Achieving Selective Cleavage Within 15 Minutes The research team designed a platform in which DNA strands of 100？1,000 base pairs (bp) are attached on both sides of the mechanophore. Experimental results showed that when the DNA structure reached a sufficient length (250 bp or longer), the cleavage rate at the mechanophore site reached about 99.9% within 15 minutes. DNA sequencing analysis confirmed that the DNA itself remained intact, while mass spectrometry precisely identified the cleavage location and pattern. Professor Kwak Min-Seok explained, “If conventional polymer mechanophores are like a ‘hammer,’ DNA mechanophores are closer to a delicate ‘surgical scalpel.’ We believe this technology has strong potential to change the paradigm of mechanochemistry research.” Potential as an Integrated Platform for Diverse Mechanophores This platform also offers a significant advantage in that mechanophores with different structures can be easily exchanged, allowing their performance to be systematically compared and evaluated. The research team screened 32 candidate mechanophores using computational analysis (the CoGEF method) and experimentally validated several of them, enabling a systematic analysis of structural differences in reactivity. Stable Operation Even Under Low-Intensity Ultrasound… Expanding Potential for Bio Applications The research team also validated the platform under various ultrasound conditions, including laboratory equipment (20 kHz), ultrasonic cleaners (40 kHz), and cosmetic devices (1 MHz). Notably, in a low-intensity 1 MHz ultrasound experiment conducted under skin-like conditions, the system achieved over 80% selective bond cleavage without causing DNA damage, confirming its potential for practical use under medical ultrasound conditions. The research team plans to expand this platform by integrating it with various biomaterials, such as DNA nanostructures and nanoparticle assemblies, enabling applications including ultrasound-triggered drug delivery systems, ultrasound-based biosensors, and smart therapeutic materials that respond to mechanical stimuli. The study is regarded as particularly significant because it combines DNA technology with polymer mechanochemistry, laying the groundwork for a new research field that enables precise control of molecular reactions using ultrasound. This research was supported by the Nano and Materials Technology Development Program of the Ministry of Science and ICT and the National Research Foundation of Korea, as well as the Future Technology Research Lab and InnoCORE programs of the Ministry of Science and ICT, and the Regional Leading Research Center Program of the Ministry of Education.
대외홍보센터 (2026-03-11)COUNT 5Pukyong National University Research Team Identifies the Urban Heat Island as a “Day-Night Thermal Asymmetry Structure”- Published in the international journal
Professor Sei-Jung Lee’s Team Develops a Next-Generation Colon-Targeted Drug Delivery Technology for Inflammatory Bowel Disease Pukyong National University (President Baesang Hoon) announced that the research team led by Professor Sei-Jung Lee from the Division of Smart Healthcare, Major in Human Bio-Convergence, has developed a next-generation oral drug delivery system that selectively delivers medication to inflamed regions of the colon for the treatment of inflammatory bowel disease (IBD). Professor Lee conducted this collaborative research with Professor Changhyung Choi from the Department of Chemical Engineering at Yeungnam University. The study was published in the February issue of Materials Today Bio (Impact Factor 10.2). The research team focused on pentoxifylline, a drug widely used to improve blood circulation, which is known to possess anti-inflammatory and immunomodulatory properties. Despite its therapeutic potential, conventional oral administration has limited its application in colitis treatment because the drug is either degraded in the stomach or rapidly eliminated from the body before reaching the colon. To overcome these limitations, the team developed a pH-responsive microcapsule system encapsulating pentoxifylline in hair-thin particles. The capsules remain stable under the highly acidic gastric environment but swell and release the drug selectively under neutral pH conditions corresponding to the colon. This targeted delivery approach enables the drug to remain longer at inflamed sites in the colon while minimizing systemic distribution. As a result, therapeutic efficacy was significantly enhanced even at lower doses. In animal models of colitis, treatment with the microcapsule system markedly improved symptoms such as body weight loss, diarrhea, and colon shortening. Histological analysis further demonstrated substantial reductions in tissue damage and inflammatory responses. Additionally, the treatment helped restore gut microbiota composition toward normal levels. Ms. Ji-yeon Park, a second-year master’s student in the Department of Human Bio-Convergence, served as the first author and played a leading role in conducting the experiments and data analysis. She stated, “With the guidance of my advisor and the support of our lab members, I was able to successfully complete this research. I hope this technology will ultimately contribute to effective therapeutic strategies for patients with colitis.” Professor Lee commented, “Since inflammatory bowel disease requires long-term management, it is essential to develop delivery technologies that ensure drugs act precisely where they are needed. This study demonstrates a new therapeutic potential for an existing drug.” He added, “We will continue advancing microcapsule- and microneedle-based drug delivery platforms to develop innovative treatments for refractory inflammatory diseases.” Meanwhile, Professor Lee’s research team is actively pursuing next-generation biopharmaceutical development based on advanced drug delivery technologies and fostering interdisciplinary research and training in the field.
대외홍보센터 (2026-03-11)COUNT 5Pukyong National University Develops a 3D Printing-Based Platform for High-Speed, Large-Scale Production of Emulsion Microcapsules- Enables highly uniform, continuous manufacturing, laying the groundwork for the commercialization of drug delivery systems and biocapsulesA research team led by Professor Hwang Yun-Ho (Major in Polymer Engineering) at Pukyong National University has developed a microfluidic platform capable of the large-scale production of double-emulsion-based microcapsules using 3D printing technology. This study was conducted in collaboration with the research team of Professor Kim Dong-Pyo at POSTECH (Pohang University of Science and Technology). Going beyond conventional single-emulsion generation techniques, the work is significant in that it presents a scalable process platform for the fabrication of functional microcapsules. An emulsion is a formulation composed of two immiscible liquids, and a conventional single emulsion is widely used in the food, cosmetics, and pharmaceutical industries. However, to fabricate microcapsules such as drug delivery carriers, functional capsules, and particles with protective layers, it is essential to produce double emulsions, which allow simultaneous control of the inner core and outer shell structures. The structural uniformity of double emulsions is a key factor that determines the size, shell thickness, and release characteristics of microcapsules. While the conventional bulk emulsification method is advantageous for mass production, it has limitations in producing uniform microcapsules because it is difficult to precisely control the structure of double emulsions. Accordingly, recent studies have focused on using microfluidic technologies to generate uniform double emulsions and employ them as templates for microcapsule fabrication. However, existing microfluidic devices still face challenges, including low production throughput and unstable long-term operation due to issues such as non-uniform flow distribution, making sustained, stable microcapsule production difficult. To overcome these limitations, the joint research team newly designed and fabricated a parallelized microfluidic platform using 3D printing technology. The team also developed a 3D printing？based surface treatment technique capable of producing double emulsions, which are essential for microcapsule fabrication. Because 3D printing materials are generally chemically stable, it is difficult to render their surfaces hydrophilic; however, the researchers overcame this challenge by uniformly coating the inner surfaces with silica nanoparticles under acidic and high-temperature conditions. Through this approach, they achieved, for the first time, the continuous and large-scale production of microcapsules using double emulsions on a 3D printing？based platform. This platform enables the stable, simultaneous operation of multiple double-emulsion generators and demonstrates the mass production of microcapsules templated by double emulsions with high uniformity and reproducibility. In particular, by precisely controlling the internal core ratio and shell structure, the team has established a foundation for designing the release characteristics of microcapsules. Professor Hwang Yun-Ho explained, “This research goes beyond the development of a microcapsule manufacturing platform. By enabling precise control over the structure and release characteristics of microcapsules, it offers both significant academic value and strong potential for commercial applications. It can be broadly applied to technologies such as drug delivery systems, bio capsules, and the encapsulation of functional materials.” Meanwhile, the results of this study were recently published in the ‘Chemical Engineering Journal’ (IF:13.2), a top-tier international journal in the field of chemical engineering.
대외홍보센터 (2026-03-11)COUNT 5Pukyong National University Team Led by Professor Lim Do-Jin Develops the World’s First “General-Purpose Droplet Control Algorithm”- Breakthrough solves long-standing challenges in CCEP-based digital microfluidics; published in
Professor Lee Seong-il’s Research Team Proposes Measures to Reduce Seabird Bycatch on Distant-Water Fishing Vessels- Published in the international journal
Pukyong National University Identifies Key Mechanism of ‘Hadley Circulation,’ a Longstanding Climate Science Challenge？ Professor Moon Woo-seok’s Research Team Reveals Mid-Latitude Storms as the Cause of Tropical ExpansionA new explanation has been proposed for why the Hadley cell―a fundamental component of Earth’s climate system―is expanding toward the poles. Professor Moon Woo-seok from the Department of Environmental Atmospheric Sciences at Pukyong National University and his research team have revealed that mid-latitude storms, also known as baroclinic eddies, are the main cause of this phenomenon, which has long been considered one of climate science’s great mysteries. The Hadley cell is a large-scale atmospheric circulation system composed of rising air in the tropics and sinking air in the subtropics. It plays a crucial role in shaping global precipitation patterns, desert formation, and the position of jet streams. Although observations and models over the past few decades have consistently shown that the boundary of the Hadley cell is shifting poleward, the cause of this phenomenon has remained unclear. The dominant explanation until now has been the 1980 Held & Hou model, but it fails to account for the critical role of mid-latitude storms in the actual atmosphere. Professor Moon extended this classical theory by incorporating the heat and momentum transport of mid-latitude storms and, for the first time, proposed an energy-based mechanism that determines the expansion and contraction of the Hadley circulation. According to the study, when mid-latitude storms transport more energy into the mid-latitudes, the Hadley cell contracts and strengthens; conversely, when less energy is transported, the Hadley cell expands toward the poles and weakens. As global warming progresses, the frequency and intensity of mid-latitude storms are decreasing, weakening the energy transport from the equator to the mid-latitudes―this is presumed to be driving the expansion of the Hadley circulation. This finding clearly demonstrates that changes in the Hadley cell are not merely a tropical issue but are closely linked to mid-latitude weather systems. Professor Moon Woo-seok’s research clearly demonstrates that changes in midlatitude storms may become a key driver of future tropical expansion. Since variations in the Hadley circulation directly impact major climate factors such as global precipitation patterns, the expansion of drought-prone regions, and shifts in jet streams, this newly proposed mechanism carries significant implications for future predictions in the era of climate change. Professor Moon published the findings in two papers titled ‘Influence of Baroclinic Eddies on the Hadley Cell Edge’ and ‘Midlatitude Interactions Expand the Hadley Circulation’, which were recently featured in the prestigious international journals
Pukyong National University Develops Lead-Free X-ray Shielding Aerogel- 3D photon cage structure achieves up to 97% X-ray absorption efficiency- Published in world-renowned chemistry journal Advanced Functional MaterialsProfessor Kim Jeong-hwan’s team at Pukyong National University (Department of Advanced Materials System Engineering) has developed a next-generation X-ray shielding aerogel material that is flexible, super-elastic, and hydrophobic. X-ray technology is widely used in fields such as medicine, science, industry, and the military, but exposure to X-rays poses potential risks to the human body. The lead (Pb)-based shielding materials currently in widespread use have several limitations, including toxicity, environmental hazards, and poor flexibility. In particular, lead exhibits low X-ray absorption efficiency in the 40？88 keV range and is inadequate in blocking secondary radiation generated by interactions between X-rays and the shielding material. Although various studies have sought to overcome these limitations, most existing research has focused on two-dimensional (2D) flexible thin-film alternatives to lead. However, these approaches have been constrained by limited attenuation cross-sections, which fundamentally restrict the improvement of X-ray absorption performance. Recognizing this, Professor Kim Jeong-hwan’s team focused on three-dimensional (3D) porous aerogels, which possess low density and high flexibility. Within their complex pore networks, repeated photon absorption, scattering, and reabsorption increases photon dwell time, significantly enhancing absorption efficiency. By applying a gadolinium (Gd)-based phase separation-induced strategy, the team successfully developed a flexible aerogel with a 3D “photon cage” structure. They further enhanced the material by adding a polydimethylsiloxane (PDMS) coating and incorporating a perovskite compound, Cs₃Bi₂I？. As a result, they created a next-generation X-ray shielding material with excellent properties―super elasticity, hydrophobicity, thermal insulation, and freeze resistance―while achieving four synergistic X-ray absorption mechanisms. The aerogel developed by the research team demonstrated excellent X-ray shielding performance across a wide energy range, thanks to the synergistic effects of its four complementary absorption mechanisms and the photon cage structure. In experimental tests, the material achieved a high X-ray absorption efficiency of 76？97% within the tube voltage energy range of 40？120 kV. To assess the aerogel’s real-world applicability in medical environments, the research team conducted joint performance verification tests using CT equipment in collaboration with Samsung Medical Center. Professor Kim Jeong-hwan stated, “This achievement proposes a new structural design paradigm for developing high-efficiency, lightweight, and flexible X-ray shielding materials, and holds great potential for future applications in medical, military, and industrial fields.” The study was supported by the Ministry of Science and ICT, the Ministry of Education, and the National Research Foundation of Korea, as well as by the Global Joint Research Program at Pukyong National University. The results were published in the prestigious international chemistry journal
Pukyong National University Develops Stretchable and Contractible Gelatin-Based Electronic Skin- Research teams led by Professors Kim Yong-hyun and Park Myung-ki … propose potential for AI wearable platforms A gelatin-based hydrogel sensor that is soft like human skin and highly stretchable―with minimal disruption to electrical signals even after repeated stretching and relaxation―has been successfully developed. A research team led by Professor Kim Yong-hyun (Department of Display and Semiconductor Engineering) and Professor Park Myung-ki (Department of Chemistry) at Pukyong National University (President Bae Sang-hoon) developed this material, which can reliably detect both subtle human movements and larger joint motions. When attached to the skin, the material collects signals that, once analyzed through artificial intelligence (AI), can accurately distinguish different human motions. This positions it as a promising next-generation wearable electronic skin (e-skin) platform. The research team created a soft and elastic base structure resembling human skin by combining gelatin―derived from porcine skin collagen―with glycerol and polyethylene glycol. They then applied a hybrid conductive network composed of silver nanowires (AgNWs) and a conductive polymer (PEDOT:PSS) to achieve high electrical conductivity and durability. To ensure long-term stability in both form and performance, a glutaraldehyde crosslinking process was used to tightly bind the molecular structure. The most notable feature of the resulting hydrogel sensor is its extremely low electrical hysteresis (signal distortion). Typically, when a sensor is stretched and released, the electrical signal can become misaligned, causing inconsistent measurements. However, this material maintains signal distortion under 3.5% even when stretched up to 200%, enabling it to consistently deliver stable signals for the same movement. It also demonstrated excellent durability, retaining performance after more than 1,000 cycles of repeated deformation. Notably, this hydrogel sensor was able to precisely detect not only large body movements―such as finger bending, arm and knee joint motion, walking, and jumping―but also fine physiological signals like pulse, respiration, and facial expression changes when attached to human skin.The research team connected the sensor to a wireless system to transmit data in real time, which was then analyzed using artificial intelligence (AI). As a result, they successfully classified 13 different types of movements with approximately 97.7% accuracy. The research findings were published in the world-renowned journal in the field of chemical engineering,
Pukyong National University Develops Interface Control Technology for Next-Generation All-Solid-State Battery Cathodes- Research by Professor Oh Pil-geon’s Team Published in Chemical Engineering Journal, a Leading Chemistry Journal Pukyong National University (President Bae Sang-hoon) announced that a research team led by Professor Oh Pil-geon from the Department of Nano Fusion Engineering has developed a new interface control technology for cathodes used in next-generation all-solid-state batteries. The team’s recent study focused on the interface characteristics of single-crystal cathode active material NCM811 for sulfide-based all-solid-state batteries. The research findings were published in the
Pukyong National University Research Team Uncovers Mechanism to Enhance Ion Conductivity in Solid Electrolytes-Research by Prof. Jung Sung-chul’s team published in Journal of Materials Chemistry A, Royal Society of Chemistry (RSC)-Study proposes strategy using cation substitution for charge control and improved ion conductivityPukyong National University (President Bae Sang-hoon) announced on the 13th that a research study by Professor Jung Sung-chul (Department of Physics) and his team on enhancing ion conductivity in solid electrolytes has been published in an international journal of the Royal Society of Chemistry (RSC), UK. The research team, led by Professor Jung Sung-chul of Pukyong National University and Dr. Jeon Tae-gon, a postdoctoral researcher from the LAMP Project Group, identified the mechanism behind the significant improvement in ionic conductivity of the argyrodite-type solid electrolyte Li6SbS5I for all-solid-state batteries, achieved through cation substitution. This result is considered a meaningful achievement in the growing field of solid electrolytes, which are being actively explored as safer alternatives to liquid electrolytes prone to fire hazards. Using first-principles calculations, the team discovered that when the cation Sb in the SbS₄ tetrahedron of the Li6SbS5I solid electrolyte is substituted with Si, the Si provides more electrons to the neighboring sulfur anions. These electron-rich sulfur anions then strongly interact with lithium cations passing nearby, drastically lowering the diffusion barrier for lithium ions. As a result, the ionic conductivity of this solid electrolyte increased significantly―from 4.4 × 10-⁴ mS cm-¹ before substitution to 15.4 mS cm-¹ after substitution. This is one of the highest levels ever reported for solid electrolytes used in all-solid-state batteries and is considered by the research team to be competitive with the ionic conductivity of conventional liquid electrolytes in lithium-ion batteries. Professor Jung Sung-chul stated, “This study demonstrates that the strategy of charge modulation―adjusting the charge around lithium-ion diffusion paths through aliovalent cation substitution―is highly effective in enhancing the ionic conductivity of argyrodite-type solid electrolytes.” This research was supported by the Ministry of Education’s LAMP (Leaders in Advanced Materials Platform) program. The findings were published in the prestigious international journal Journal of Materials Chemistry A (Impact Factor: 9.5), issued by the Royal Society of Chemistry, under the title: “Conductivity enhancement of argyrodite Li6SbS5I solid electrolyte via charge modulation around Li diffusion paths through Si substitution.”
대외홍보센터 (2025-11-28)COUNT 121Joint Research with SNU Hospital on Artificial Esophagus Development Pukyong National University (President Sang-hoon Bae) announced that a research team led by Professor Seung Yun Nam in the Department of Biomedical Engineering has developed an integrated biofabrication technology for artificial esophageal reconstruction, in collaboration with Professor Eun-Jae Chung’s team at Seoul National University Hospital. Esophageal reconstruction is typically performed using gastric or colonic segments when the organ is severely damaged by malignancy, corrosive injury, or trauma. However, these autologous conduits often show mismatched mechanical properties, inflammatory reactions, poor tissue integration, and impaired peristaltic motion, frequently leading to postoperative complications. To address these limitations, Professor Seung Yun Nam’s team developed a next-generation biomimetic artificial esophageal scaffold designed to recapitulate the hierarchical structure, mechanical behavior, and functional microenvironment of native esophageal tissue. In this study, the team used electrospinning to fabricate highly elastic and durable polyurethane (PU) nanofibers as the primary structural framework of the scaffold. Additionally, embedded digital light processing (DLP)-based photopolymerization was employed to incorporate silk fibroin methacryloyl (Sil-MA) within the PU nanofiber network, thereby enhancing tensile strength, elastic modulus, and surface hydrophilicity. In a subsequent step, precision extrusion bioprinting was used to laminate a layer of decellularized esophageal extracellular matrix (EdECM) onto the construct, effectively reconstructing a tissue-specific microenvironment analogous to that of the native esophagus. The resulting PU/Sil-MA/EdECM composite scaffold exhibited substantial improvements in both mechanical robustness and biological performance. The structure showed markedly enhanced tensile strength, elasticity, and surface wettability, leading to significantly increased stem cell adhesion, proliferation, and focal adhesion formation. In vitro studies further demonstrated superior smooth muscle and epithelial cell differentiation, critical for restoring esophageal motility. In a rat model with a circumferential esophageal defect, the engineered scaffold showed excellent tissue integration, reduced inflammatory cell infiltration, and robust regeneration of smooth muscle, epithelium, vasculature, and peripheral nerves. Contrast swallow studies and functional assessments confirmed recovery of peristaltic motion and stable luminal patency, highlighting the scaffold’s strong potential for future clinical translation. Professor Nam stated, “This work is the first to recreate both the structural complexity and mechanical properties of the esophagus by combining electrospun PU, DLP-patterned Sil-MA, and ECM-based bioprinting. It represents a powerful fabrication strategy capable of engineering tissue-specific mechanical behavior and promoting coordinated regeneration in esophageal reconstruction.” The research was published under the title “Integrated Biofabrication of Artificial Esophageal Scaffolds using Electrospinning, Embedded DLP, and Extrusion Techniques” in the online edition of Materials Today Bio (Impact Factor: 10.2, JCR Top 7.2%), one of the leading international journals in the field of biomaterials and regenerative medicine. The study was supported by the Health Technology R&D Project of the Korea Health Industry Development Institute (HI22C1323) and involved collaborative contributions with researchers at Seoul National University College of Medicine, University of Ulsan College of Medicine, The Catholic University of Korea College of Medicine, Inje University, and ATEMs. [https://doi.org/10.1016/j.mtbio.2025.102518]
대외홍보센터 (2025-11-28)COUNT 141Promising Startup Technology for Cancer and Disease Diagnosis Using Metal Nanoanalysis Recognized-Professor Nam Won-il Secures Double Honors in Government Startup Support Programs-Selected for Both the Lab-Based Startup Leading University and Preliminary Startup Package ProgramsProfessor Nam Won-il of Pukyong National University’s Department of Electronic Engineering and his research team have been selected for multiple government startup support programs, thanks to their cutting-edge biotechnology. The team was recently selected for both the “Lab-Based Startup Leading University (Strategic Type)” program―jointly operated by the Ministry of Science and ICT, Ministry of SMEs and Startups, and Ministry of Education―and the “Pre-Startup Package (Deep Tech)” program led by the Ministry of SMEs and Startups. In particular, Professor Nam Won-il was recognized for the high potential of his innovative biotechnology startup in the bio-health sector, being one of only 12 selected nationwide for the deep-tech program. Professor Nam Won-il’s research team at Pukyong National University operates the Nanoplasmonics Laboratory and is leading the development of surface-enhanced Raman spectroscopy (SERS), a next-generation analytical technology. SERS is an ultra-sensitive analytical method that utilizes the enhancement of molecular fingerprint signals (Raman scattering) on metallic nanostructure surfaces, enabling the detection of molecules at extremely low concentrations, even at the single-molecule level. This technology allows both qualitative and quantitative analysis in a non-destructive and label-free manner. It is also applicable to aqueous biological samples and bio-specimens based on the weak Raman signals of water molecules, drawing increasing attention in the fields of bioanalysis and diagnostics. The core technology developed by Professor Nam Won-il’s team―a high-performance, large-area SERS biochip―addresses two long-standing limitations of conventional SERS sensors: reproducibility and sensitivity. By combining a 3D nanoantenna structure with a soft lithography process, the research team successfully fabricated SERS biochips that are suitable for large-area, high-volume production. This achievement has earned recognition for its strong potential for commercialization in the rapidly growing precision bio-diagnostics market. Professor Nam stated, “SERS chips can be applied not only to cancer and disease diagnosis or monitoring, but also to a wide range of fields such as water pollution detection, food safety, and environmental analysis,” adding, “We plan to actively pursue deep-tech-based technology commercialization beyond fundamental research.”
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